Sentence examples for observation that down from inspiring English sources

Indeed, a large body of earlier, groundbreaking work showing that calorie restriction [ 10, 11] or down regulation of insulin/IGF-1 signaling [ 12, 13] extends life span is consistent with the observation that down regulation of TOR also extends life span.

The APP gene is located on chromosome 21, which had been linked to AD by multiple genetic linkage studies and the observation that Down's syndrome patients develop dementia accompanied by prototypical neuropathological hallmarks of AD [ 8, 9].

The observation that down-regulation of MHC class I surface expression renders hMSCs vulnerable to NK cell recognition and cytolysis implies that multiple viral immune evasion proteins are likely required to make hMSCs non-immunogenic and thereby universally transplantable.

This view is mainly based on the observation that down-regulation of the IFC-2 protein induces multiple bubble-shaped invaginations of the lumen into intestinal cells, suggesting the occurrence of an increased epithelial fragility [ 30].

The observation that down-regulation of DLC1 in NSCLC is associated with a poor clinical outcome [ 39] implies that targeting pro-oncogenic pathways activated by this down-regulation could be especially useful therapeutically, and inhibition of the RhoA pathway and Rho kinase, a downstream effector of Rho, are promising options for therapeutic interventions.

In addition, CaM binding proteins, such as maize pollen calmodulin-binding protein (MPCBP) and NPG1 (no pollen germination1) in Arabidopsis, are specifically expressed in pollen and regulate pollen germination, as supported by the observation that down-regulation of these genes resulted in the inability of the pollen to germinate [ 34, 35].

Our observation that knocking down H19 upregulates IGFBP4, which counteracts the tumor promoting activity of IGF2, could provide a link in trans between H19 and IGF2.

The observation that the down regulation of genes involved in these pathways may point to a low adaptability of this Italian variety to low temperature stresses.

Of note is the observation that knocking down FGFR3 expression in RT4 cells led to a dramatic decrease in cell viability in normoxia and hypoxia, concomitant with a decrease in the activation of PKB and MAPK signalling.

The interesting observation that pramipexole down-regulated DAT-IR in saline treated mice suggests that DAT regulation plays a role in neuroprotective effects of pramipexole.

Nevertheless, the observation that knock-down of PKP2 affects Cx43 expression and localization as well as cell coupling properties supports our hypothesis that desmosomal proteins are essential for proper gap junction function.