Observation outcomes showed pathway layout encourages behaviour, use and time spent in sensory areas.
Finally, a cross-sectional study design has several inherent weaknesses, such as lack of long-term observation for outcome and difficulty interpreting the association of exposure with outcome.
◆ Detection bias: differences in observation of outcome parameters, e.g. due to inadequate blinding and respective expectations by assessors, due to training effects or others.
It is important to realise that the unit of randomisation, observation and outcome measurement need not necessarily all be the same.
In addition, the duration of observation and outcome of AEs were often not established, with about 30%% of cases of hepatotoxicity not followed up to identify whether resolution had occurred.
These data are supported by the observation that outcomes are not significantly better, if at all, for reconstruction following traumatic ossicular discontinuity, [11, 12] a situation in which chronic infection and Eustachian tube dysfunction are not usually a factor.
However, the positive results of these investigations were based on behavioral tests to assess the extent of regained functional activity, while the studies do not provide insight into the physiological mechanisms underlying the observations of outcome improvement.
1) The authors do not establish whether their observations regarding SOX2 are relevant to any important clinical observation or outcomes.
Thus in our main analyses we discarded the first two years of observation and outcomes detected during this period.
Specific points: 1) The authors do not establish whether their observations regarding SOX2 are relevant to any important clinical observation or outcomes.
