Observations for mortality were made once every 4 hours from 18 to 60 hours post infection.
The rats were weighed and visual observations for mortality, behavioral pattern (Salivation, fur, lethargy, and sleep), changes in physical appearance, injury, pain and signs of illness were conducted once daily during that period.
The rats were weighed and visual observations for mortality, behavioural pattern (salivation, fur, lethargy, and sleep), changes in physical appearance, injury, pain, and signs of illness were conducted once daily during the period.
Rates based on 1 to 5 observations for incidence and 1 to 4 observations for mortality were suppressed for confidentiality purposes Probabilities of developing and dying from cervical cancer were calculated for age-specific mortality (1952, 1972 and 2006) and incidence (1972 and 2006).
The observation period for mortality was of 30 days in all groups.
Mortality and adverse outcome decreased significantly over the three 3-year observation periods (for mortality: 44%, 32%, 28%; p = 0.01; for adverse outcome 52%, 39 %, 33; p = 0.001; Figure 1).
In the largest trials of hydroxyethyl starch in sepsis the relative risk of death increased from day 28 to day 90, indicating that the observation period for mortality should be longer than 28 days, and this was the rationale for our subgroup analysis.
By December 2013, 326 deaths had occurred during 8966 person-years of observation, for a mortality rate of 3.6 per 100 person-years [95 % confidence interval (CI) (3.3, 4.0)].
All mice were allowed for food ad libitum for 14 days and kept under regular observation for any mortality or behavioral changes (irritation, restlessness, respiratory distress, abnormal locomotion, and catalepsy etc).
