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Dr Tagliavini's team has been following up this observation by testing IDX on hamsters infected with scrapie, a prion disease that normally occurs in sheep.Prion diseases are all about proteins.
We confirmed this observation by testing co-precipitation of Twi1p and Giw1p in DCL1 KO cells, in which Twi1p is in an unloaded state due to lack of scnRNAs (Malone et al, 2005; Mochizuki & Gorovsky, 2005).
We validated this observation by testing the enrichment of differentially expressed genes among differentially methylated genes (Fig. S2), where 248 out of 819 hypomethylated genes were activated, and 174 out of 291 hypermethylated genes were repressed (Fisher exact test, P < 0.05 in both cases).
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We explore the biology significance of these observations by testing if Pin1 blockade would alter type 1 immune responses to mismatched organ transplants.
In the present study, we sought to extend these previous observations by testing whether conditional inactivation of Brca1 and p53 in the ovarian surface epithelium in situ is sufficient to establish an autochthonous mouse model of BRCA1-associated invasive EOC.
We confirmed these observations by testing sensitivity of human skin melanoma cell line, C32 (Table 1).
Finally, we decided to investigate the generality of our observations by testing whether ELAV was capable of exerting any effects on the expression of other Hox genes within the nervous system.
We investigated this observation further by testing whether endogenous Atg36 can restore mitophagy in cells lacking the mitophagy receptor Atg32.
These observations were confirmed by testing recombinant vRNPs derived from a clade 1 H5N1 virus (A/VN/1203/03) and the WSN (data not shown).
We aimed to test the observations made in our former trial by testing the a priori hypothesis that a lower dose of vitamin A compared with the recommended dose is associated with lower mortality in girls.
However, when this observation was tested by clonal analysis, rather than in homozygous mutant animals, Gmd clones did not have an obvious phenotype.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com