Therefore, observations accrued here might not be extrapolated to patients with AKI elsewhere.
The details and observations accrue in such a way — obliquely, melodiously — that they pull a reader forward in anticipation of the next unexpected leap: a stray object, an odd gesture, a bald declaration, or a rash act.
Person-time of observation were accrued from the initiation on NVP-based ART until either occurrence of death, loss to follow-up, transfer to another ART programme or censoring of observation in July 2007.
During the study period 2001 through 2010, there were 144,308 distinct individuals in the database and they accrued 798,542 person-years of observation.
For an observation to be generalizable, the proportion of patients accrued for the trial must be comparatively large and representative of the condition in the community.
Median observation time was 22.5 months [IQR 10, 36], and total person-years accrued during follow-up was 4,717.
We therefore conducted a 13-year prospective observation of 41 965 Japanese adults aged 40 79 years living in the community, which accrued 392 860 person-years.
The Eastern Cooperative Oncology Group (ECOG) 1684 trial was a prospective, randomized, controlled trial of high-dose IFNa-2b (HDI) versus observation in high-risk (Stage IIB and Stage III) resected melanoma that accrued patients between 1984 and 1990.
This observation suggests that each group of assessors brings something valuable to student assessment, and that omitting comments from one group would lead to the loss of observations from specific areas of student performance; as Lockyer and Clyman write, "additive value is accrued from comparison of multiple sources" [ 26].
After 21 patients had been accrued, the DLT window was expanded to 42 days (1.5 cycles), based upon the mid-study observation that many patients required dose reduction for toxicity early in cycle 2, as discussed below.
