Exact(6)
Finally, we show that mutation of all identified phosphorylation sites does not cause observable defects in growth rate or morphology.
Morpholino-based knock-down of A2ML does not block the initial formation of the liver primordium, but growth and development of the liver is disrupted largely by reduced cell proliferation, without observable defects in pancreas and intestine development.
Surprisingly, mutagenesis of these putative phosphorylation sites (including those matching consensus sequences for CDK or PAK family kinases and those not) has not resulted in any observable defects in cell polarization and growth by a variety of assays, suggesting that phosphorylation is largely dispensable for the regulation of Cdc24.
GRAF1-depleted cells had no observable defects in their ability to endocytose transferrin, demonstrating that GRAF1 is not necessary for Clathrin-mediated endocytosis.
Dynamic contrast-enhanced MRI is more objective and reliable for the accurate assessment of ablation results because it uses signal changes and observable defects in the blood flow supplied to ablated lesions.
The importance of Mcl-1 in regulating neutrophil survival is revealed by myeloid specific deletion of Mcl-1 in mice, which leads to neutropaenia without any observable defects in macrophage number or function (54).
Similar(54)
To determine whether cells that are relatively insensitive to AprA have an observable defect in the ability of rAprA to bind to this receptor, we measured binding of rAprA to cells.
This screen has provided the first evidence that links a genetic change to an observable defect in S. rosetta's development: in other words, it has linked genotype to phenotype in a choanoflagellate that forms colonies.
While PbCnA-AID depletion resulted in significant reduction in erythrocyte invasion, PbCDPK1-AID demonstrated no observable defects.
Hematoxylin and eosin (HE) staining revealed that the earliest observable defects occurred at P7 when a significant portion of germ cells in both geAip1−/− and seAip1−/− testes failed to relocate to the basement membrane.
There are almost no observable defects across the entire NWs length.
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