In this study, the Neur2−/− and Neur1&2DKO mice also were grossly healthy without any observable abnormality.
Hip-eEF-2K-tg mice showed normal viability without observable abnormality in growth, body size, and mating, eating, and general behaviors, compared to those in their wild-type littermates (data not shown).
At 1 2 weeks after the initial onset of an observable abnormality, both legs of βLKB1KO mice became paralyzed.
Although there were no observable abnormalities in soma of motor neurons (data not shown), we observed the degenerative and swollen axons with the accumulation of granular aggregates, disorganized fibrillar materials, multivesicular bodies (MVBs), and/or autophagosome-like vesicles in the spinal cord of Als2−/−;SOD1H46R and Als2+/+;SOD1H46R mice at an early symptomatic stage (Figure 3B and 3C).
Microscopic analyses of histologic tissue sections revealed that there were no observable abnormalities in various tissues, including the brain (Figure 1E, not shown).
Typically 80% of embryos targeted using these conditions survive through the swimming tadpole stage with no observable abnormalities.
The current paper tested the hypothesis that such deficits are the result of observable abnormalities in search behaviour (e.g., attention-onset, -duration and -sequencing), and therefore can be explained without reference to deficits in non-observable (i.e., cognitive) processes.
The general health and well-being of the mice were monitored by veterinary staff with careful observation of activity, nest building, and interaction with cage mates and by physical examination, providing an assessment of the animals' hydration, body condition, and observable abnormalities.
MCM was defined according to the International Dairy Federation (IDF) [ 4], observable abnormalities in milk, generally clots or flakes; little or no signs of swelling of the udder or affected quarter; no other signs that the cow is unwell, no fever, and normal appetite.
Diagnosis of less-severe stages of osteoporosis is a complicated matter because the condition is not associated with measurable chemical abnormalities or with observable tissue abnormality other than a decrease in bone mass.
The corresponding FLAIR signal abnormality is typically present, generally with no observable abnormal susceptibility or enhancement.
