Exact(14)
Support the interpretation that the partner intermixing observed by the authors is limited to obligatory cooperation.
10.7554/eLife.00230.022 Figure 4. Obligatory cooperation through redox-coupling leads to partner intermixing.
Experimentally, obligatory cooperation and obligatory commensalism led disparate initial ratios to converge.
In engineered yeast communities, obligatory cooperation and obligatory commensalism allow initially different partner ratios to converge over time.
This result is intuitive: facultative cooperation should resemble obligatory cooperation if fitness benefits are large for both partners.
Seems to support the interpretation that the partner intermixing observed by the authors is limited to obligatory cooperation.
Similar(46)
Shou et al. (2007) constructed a synthetic obligatory cooperative system, termed CoSMO (cooperation that is synthetic and mutually obligatory), which consists of a pair of auxotrophic yeast strains, each supplying an essential metabolite to the other strain.
In obligatory commensal communities, R → A ← L took in lysine from the media and overproduced adenine to feed the adenine-requiring G ← A. In obligatory cooperative communities (previously described as Cooperation that is Synthetic and Mutually Obligatory, or "CoSMO"), R → A ← L overproduced adenine and required lysine while G → L ← A overproduced lysine and required adenine (Shou et al., 2007).
A minimal synthetic obligatory cooperative system has also been engineered by Shou et al. [ 21] to study cooperation as well as the conditions that allow viability between two auxotrophic strains of yeast, each producing a substrate essential for the other.
To test the prediction that strong cooperation is the only ecological interaction capable of driving partner intermixing, we engineered yeast communities engaged in competitive, obligatory commensal, and obligatory cooperative metabolic interactions.
We have observed cooperative intermixing in the fitness model simulating strong facultative cooperation and in obligatory experimental systems including engineered yeast communities and syntrophic biofilms.
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