Sentence examples for obligate step for from inspiring English sources
Human GMPK is an obligate step for the activation of acyclic guanosine analogs, such as ganciclovir, which necessitate efficient phosphorylation, while GMPK from bacterial pathogens, in which this enzyme is essential, are potential targets for therapeutic inhibition.
Our data support a model whereby eHsp90-LRP1 dependent signaling is an obligate step for AKT activation and subsequent AKT directed phosphorylation of EphA2.
There is, however, evidence that interaction between channel subunits is an obligate step for their correct folding and insertion into the plasma membrane [7], [8].
While facultative for the majority of parasite pathogens, gametogenesis and fertilization are obligate steps of the Plasmodium life cycle (Heitman, 2010), consequently, disrupting either process prevents infection of new hosts.
Therefore, our data illuminate a novel crosstalk mechanism whereby eHsp90-LRP1 sisnaning is an obligate step in AKT mediated P-EphA2S897 antivation, an event required for subsequent GBM cell invasion.
This de novo cytochrome is capable of reversible oxygen binding, an obligate step in the catalytic cycle of many oxygen-activating oxidoreductases.
An obligate step in the enzymatic activation of Vav1 is the phosphorylation of tyrosine 174 [174.
If indeed Pro isomerization was an obligate on-pathway step for the formation of the helical folded state, CEST dips would not be observed for this process because of the slow rate of exchange between cis and trans Pro.
This study supports possible toxic membrane disruption by demonstrating membrane binding, an obligate first step in such a process.
Four other associate justices -- John Paul Stevens, David H. Souter, Ruth Bader Ginsburg and Stephen Breyer -- said the court was obligated to step in when the maps of political districts were drawn for no other reason than to put one party at an advantage over the other.
Most days, my kids pack their own lunches, but since I had banned the standard ingredients, starting with the bread for peanut-butter-and-jelly sandwiches, I figured I was obligated to step in.
