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To control for random associations, generated p-values typically must reach "genomic" levels [15], and adopting such stringent standards is likely at the expense of weak but biologically plausible associations, especially in settings with obligate limitations to sample sizes.
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Due to the acquired retroversion, patients with symptomatic FAI secondary to SCFE deformities have significant functional limitations, including obligate outward rotation when walking and during hip flexion.
Microarray-based transcriptional studies for obligate intracellular bacteria have limitations, such as obtaining RNA of sufficient quality and quantity [29], [30].
The indication for surgery in this group of patients included acquired gait disturbance (obligate out-toeing), marked limitation of hip flexion (<25°) and hip or knee pain that interfered with activities of daily living.
This interacting multiplicity of kinds of lineage, with distinct stabilisation time scales and different degrees of obligate physical connection, introduces important limitations to the standard model that our alternative presentation of an extended evolutionary ontology aims to address.
In reality how much is the relative contribution of obligate monogamy and that of opportunity limitation to human monogamy is not yet clear.
"It suggests that if a consumer can avoid paying for a certain period of time, they will enjoy a windfall," she said, adding later, "People are obligated to pay their debts, whether the statute of limitations period has run or not".
The causal agents of this trade-off have been investigated empirically in a number of plant species, indicating that hierarchical resource allocation [10], [11], pollen discounting via geitonogamy in obligate out-crossing species [1], [4], [11] and pollen limitation [12] are all important drivers in this trade-off.
The physiology and biochemistry associated with the iron-limited continuous culture of the halotolerant cyanobacterium Synechococcus PCC 7002 were also examined [ 26], and the regulatory network for acclimation of the obligate photoautotrophic fresh water cyanobacterium S. elongatus PCC 7942 to iron limitation was studied by transcript profiling recently [ 27].
On the other hand, pollen limitation is less intense in self-compatible species, compared to obligate outcrossing species [ 45].
An unexpected property of the pal strain was obligate aerobicity (see Supplemental Information), which allowed for growth under strict oxygen limitation, where the rate of oxygen to supply to the culture limits the rate of growth, a similar to condition previously shown to improve performance of the butanol fermentations (Atsumi et al. 2008).
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