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Results of the study could not be objectively validated; however, findings are similar to previous descriptive studies which did include objective validation.
A limitation of this study is its use of self reported PA that was not objectively validated via accelerometers or other physiological assessments.
Survey respondents were provided with a standard definition of EBDM before answering this question, but the results should still be interpreted with caution given they are self-reported and not objectively validated.
The study's strengths include a high response rate, the availability of objective data on knowledge about healthy habits, and the use of the extensively tested Healthy Doctor = Healthy Patient questionnaire whose primary outcome measure of self-reported counseling rates has been objectively validated [ 32].
The incidence of objectively validated response in lesions located in the lung or lymph nodes was significantly higher in patients treated with IC than with C (ORR: 23 vs 8%, P=0.012 for lung and ORR: 28 vs 7%, P=0.012 for lymph nodes); there was no difference in the ORRs for lesions located in the liver (13 vs 9%; P=0.738), pleura (27 vs 13%; 0=0197) or adrenal (14 vs 0%; P=0.242).
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Salivary cortisol levels were also measured in an attempt to objectively validate mood induction effects.
Objectively validating the improved applicability and performance of QM over classical-based models in DD will be the focus of research in the coming years along with research on the conformational sampling problem as it relates to protein ligand complexes.
However, it is difficult to objectively validate this prediction under ordinary conditions.
The analysis of the published data sets demonstrated the usefulness of the new CI by objectively validating some of the previous interpretations, while showing that other conclusions lacked statistical support.
Only three trials were identified that attempted to objectively validate independent exercise behaviour with accelerometers or heart rate monitoring (Pinto et al, 2005, 2013; Cadmus et al, 2009).
Further studies need to be performed in an observer-blinded manner to objectively validate the HD-OCT findings and establish the clinical utility of the method.
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