If confirmed by other studies, particularly with objective measures of arm use, this could have serious implications for therapy decisions.
Detection of lymphoedema is given central importance in the NICE guidelines, although its symptoms do not correlate with objective measurements of arm swelling (Schunemann and Willich, 1998).
In fact, most of our international objectives on arms control and other matters can be met much more easily with domestic actions.
The main objective of this single-arm phase II study was to determine the objective response rate of FOLFIRI3-b for patients undergoing first-line treatment of metastatic colorectal cancer.
Another primary objective of the three-arm, 26-week, open-label trial described above was to compare the glycemic control measured by reduction in HbA1c in patients treated with repaglinide/metformin FDC twice daily with rosiglitazone/metformin FDC twice daily.
Primary objective of this multicentre, single-arm phase II trial was to assess the antitumour activity of the NGR-hTNF and doxorubicin combination in terms of objective response rate, defined as the proportion of patients with complete response (CR) or partial response (PR) according to the RECIST criteria.
Although most patients reported spontaneous improvement in their symptoms there were no differences in the subjective or objective treatment arms of the study.
Given the objective of the study, a single-arm design was considered appropriate to describe a cohort of patients treated with abatacept and assess their drug utilization in accordance with the European Medicines Agency and Health Technology Assessment Programmes' recommendations.
74 The primary objective of this multicenter, open-label, single-arm Phase II study (NCT01580735) is to examine if the combination of tivantinib and erlotinib is active in subjects who have locally advanced or metastatic NSCLC with activating EGFR mutation who experienced disease progression on EGFR TKI monotherapy.
After acclimation, all eight doors opened with the objective of collecting a food reward available at the end of each arm (8 arms open, 8 arms baited).
