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Effects on symptom severity are very promising, and further research examining effects on objective disease severity and treatment adherence is warranted.
More generally, Katon et al [38] have concluded that symptoms of depression and anxiety are associated with greater symptom burden (net of objective disease severity) in a variety of conditions, including chronic lung disease, diabetes, heart disease and arthritis, suggesting that the patterns described here are relevant to adaptation.
Patients must have shown objective disease progression at study entry.
Objective disease progression was observed in 68 patients.
Patient amelioration was confirmed by a marked, persistent improvement in both subjective and objective disease activity.
Objective disease responses have been documented in five different tumor types.
In future research this should be addressed and more objective disease characteristics should be included.
The objective disease status was assessed according to the RECIST guidelines, version 1.0.
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Missing information includes costs of out-of-pocket expenses, morbidity, work absence, objective disease-related outcome measures, subjective health and patient satisfaction.
For each objective, disease-specific objectives were written for the following endocrine conditions: 1) type 2 diabetes, 2) type 1 diabetes, 3) hyperthyroidism, 4) thyroid nodules, 5) hyperprolactinemia.
36 In conclusion, from what data are available specifically for the elderly, tolterodine appears to be efficacious in terms of a reduction in objective disease-related variables (urinary frequency, urinary urgency episodes and incontinence episodes) and appears to improve quality of life for people with the condition, although this is difficult to judge with limited data.
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