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If the cancer registration process in a given country allows registrations to be recorded from a variety of sources, it is possible that the registration may be made at a later point in time than the objective date of tissue diagnosis.
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This method is based on variable annual growth of tree-rings, and provides the most objective date with an accuracy of up to a year.
Development as a global policy objective dates from the 1940s.
We invited potential participants in person or through text message explaining the objectives, date, time and venue of the FGD.
The PFS was the time from randomisation to the date of objective progression or death in the absence of objective progression.
Progression-free survival (time from start of the study treatment to date of objective tumour progression (excluding clinical deterioration without evidence of objective progression)) and DCR (CR plus PR plus stable disease ⩾6 weeks) were also determined by RECIST 1.1.
Time to progression was calculated from the beginning of cytotoxic chemotherapy until the date of objective evidence of progressive disease.
Progression-free survival was assessed from the first day of chemotherapy administration to the date of objective disease progression.
PFS was the time elapsing from the start of fotemustine therapy to the date of objective evidence of disease progression or death of the patient in the absence of documented disease progression.
Duration of response was defined in patients with a partial response as the time of initiation of therapy to the date of objective disease progression and in those patients with a complete response as the time from the date of onset of the response to the date of objective disease progression.
The availability of these genomic resources enabled us to perform a wide paleogenomic analysis on LTR-retrotransposons with the objective of dating the radiation between the Asian and the African rice species.
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