Most previous studies of tear film examinations suggest a clear relationship between eye irritation symptoms and objective alterations of the tear film [ 22, 23], making these examinations relevant to this study.
A subjective or objective clinical alteration that heralds the onset of an epileptic seizure but does not form part of it.
Prodrome is a preictal phenomenon, and it is defined as a subjective or objective clinical alteration (e.g., ill-localized sensation or agitation) that heralds the onset of an epileptic seizure but does not form part of it (Blume et al., 2001).
Secondary objectives include alteration of pain intensity and frequency of pain attacks, alteration of different aspects of pain evaluated by standardised pain questionnaires (NPI, PDI, SES), effects on quality of life (SF 36), analgesic demand, alteration of sensoric perception, incidence of postherpetic neuralgia, side effects and cost effectiveness.
No objective evidence of alteration of vision or facial sensation was observed.
Despite these caveats, sensitive and objective detection of alterations in CSF pS129 and total α-syn, which both alter over two years of progression, [ 20] would greatly aid clinical trials of novel, disease-modifying treatments targeting α-syn-related systems.
Whereas these controlled studies did not reveal a consistent pattern of objective sleep disturbances, alterations of sleep continuity were commonly reported.
Objective To analyse alterations in the vaginal flora after 2% clindamycin vaginal cream or placebo administered for the prevention of preterm delivery in high risk women.
We used Fleiss' Kappa coefficients (for categorical data) and percentage of agreement to assess inter-rater reliability of muscular chain evaluation and associated posture alterations (objective 1).
In the present study, we recruited a sample of patients with TLE and healthy controls who each underwent an identical multisequence research MRI protocol with a primary objective of mapping alterations of thalamocortical connectivity and intrathalamic integrity in TLE, and their relationship with the disease process.
