Testing with this apparatus is highly suitable for studies in the dark (Albasser et al., 2011) and also permits direct comparisons with studies of c -fos activity related to object recognition in the light (Albasser, Poirier et al., 2010).
The integration of these inputs facilitates object recognition in adults.
Wallis, G. Towards a unified model of face and object recognition in the human visual system.
This rostral-caudal perirhinal pattern is the opposite of that found for object recognition in the light [93], creating a potential double dissociation (Table 2).
Object recognition in the light in the bow-tie maze seems more reliably associated with hippocampal changes, with Fos increases found in CA3 and CA1, but Fos decreases in dentate gyrus (Albasser, Poirier et al., 2010).
The design of the experiment was identical to that used to examine c- fos activation associated with object recognition in the light (Albasser, Poirier et al., 2010), except that the experiment proper (after pretraining) was run in complete darkness.
In Experiment 5, we matched the procedures used for object recognition in the light (Experiment 2) so that recognition was tested after 1 min (10 trials) and 60 min (10 trials) in two consecutive test sessions administered on the same day (see Table 2A).
While many studies of object recognition in the light have found no apparent effects of hippocampal lesions (e.g., Aggleton, Hunt, & Rawlins, 1988; Albasser, Lin, Iordanova, Amin, & Aggleton, 2012; Forwood, Winters, & Bussey, 2005; Winters et al., 2008), other studies have reported recognition deficits (e.g., Broadbent, Squire, & Clark, 2004; Clark et al., 2000, 2001).
This relation is interesting in light of recent evidence for domain-general visual abilities relevant to object recognition, as expressed by common variance between tests of familiar and novel object recognition (Richler et al.: Individual Differences in Object Recognition, submitted; Van Gulick, McGugin, & Gauthier, 2016).
Our results showed that PTX treatment did not change object recognition memory in nonTg mice but enhanced object recognition memory in APP/PS1 mice (Figure 4B).
One goal was to compare the neural activity associated with object recognition in the dark with that in the light.
