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"We've never had this problem of young people being obese like we have today," said Gen. John Shalikashvili, former chairman of the Joint Chiefs of Staff.
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Interestingly, flies with disruption of CREB functions in the fat body shows an obese-like phenotype.
Since there was no significant change in overall body size in these flies, disruption of CREB activity in the fat body caused an obese-like phenotype.
These flies did not show a significant change in overall body size, suggesting that disruption of CREB activity in the fat body caused an obese-like phenotype.
In addition, the higher total body triglyceride content without an increase in overall body size indicates an obese-like phenotype for flies with DN-CREB expression in the fat body.
Thus, a 7-day HS diet elicits an obese-like phenotype in female flies.
These data suggest that offspring from HS-fed maternal flies are predisposed to developing an obese-like phenotype when exposed to caloric excess.
Thus, offspring from HS-fed maternal flies demonstrate a predisposition to developing an obese-like phenotype during suboptimal, HS nutritional conditions.
We observed that obese-like maternal flies, generated by an HS feeding regimen, give rise to progeny with metabolic defects characterized by altered body composition and misregulation of metabolic genes (Fig. 7).
We examined the effect of maternal caloric excess on offspring and found that a high-sugar maternal diet alters body composition of larval offspring for at least two generations, augments an obese-like phenotype under suboptimal (high-calorie) feeding conditions in adult offspring, and modifies expression of metabolic genes.
Christakis and Fowler suspect that as friends around us become heavier, we gradually change our mental picture of what "obese" looks like and give ourselves tacit permission to add pounds.
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