Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.
Vaupel, P., Schlenger, K., Knoop, C. & Höckel, M. Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.
Wang, G. L., Jiang, B. H., Rue, E. A. & Semenza, G. L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
The carotid body is a major arterial chemoreceptor that senses low O2 tension, high CO2 tension and low pH in the arterial blood.
Recent progress in elucidating the molecular mechanisms underlying the modulation of ion channels by O2 tension, which involves mitochondrial complex I, is also discussed.
To investigate the effect of low O2 tension during in vitro culture in terms of ongoing pregnancy rates in ovum donation cycles.
Zygotes were cultured in SOFaa + cumulus cells at 38.5 °C under 20 or 5% of O2 tension and high humidity for 7 days.
We tested the hypothesis that O2 administration to the mother would increase arterial O2 tension (PaO2) and cortical tissue O2 tension (tPO2) in both the normoxic control fetus and that acclimatized to high altitude, and that this effect might be greater in the high altitude fetus than that at sea level.
There was a linear correlation of brain 5-hydroxytryptophan accumulatoon to cerebral venous O2 tension.
We found that HBO exposure significantly increased the brain O2 tension whereas changes in CBF were not significant.
Compared with control rats, L-NAME administration did not change either brain O2 tension or CBF during the period of the experiment.
