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o Subjects in the moderate PA group differ significantly from subjects in the high PA group (p < 0.05).
Eight (23%) out of 35 had a history of low-energy fractures; for comparison, in the whole GOAL study, low-energy fractures were reported in 123 (4%) out of 2815 o subjects, the difference being statistically significant (p < 0.01).
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Plasma VL was higher in HAD and NPI-O subjects compared to those with no NCI.
Compared to subjects with no NCI, LPS levels were higher in HAD, sCD14 and CCL2 levels were higher in HAD, MCMD, and NPI-O, and IL-6 levels were higher in MCMD and NPI-O subjects (Figure 1C).
An additional three TACE-O subjects withdrew at their own request before completing all three angiograms.
TACE-O subjects were allowed to cross-over to bevacizumab at week 16 in the setting of progressive disease.
At week 14, 3 of 9 (33%) TACE-O subjects and 2 of 14 (14%) TACE-BEV subjects demonstrated neovascularity.
In total, 4 of 9 (44%) TACE-O subjects and 6 of 15 (40%) TACE-BEV subjects underwent TACE at week 14.
In general, TACE-BEV subjects had sustained hypertension requiring ongoing treatment, whereas TACE-O subjects had transient hypertension during and/or immediately following TACE.
Collateralization was present in 3 of 11 (27%) TACE-O subjects and 3 of 14 (21%) TACE-BEV subjects at week 10, and in 1 of 9 (11%) TACE-O subjects and 2 of 14 (14%) TACE-BEV subjects at week 14.
Recanalization was present in 3 of 11 (27%) TACE-O subjects and 3 of 14 (21%) TACE-BEV subjects at week 10, and in 3 of 9 (33%) TACE-O subjects and 4 of 14 (29%) of TACE-BEV subjects at week 14.
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