Exact(6)
Metabolites serve as an effective bridge that helps to translate information about nutrient states into specific interpretations of the genome.
In C. elegans, the feeding state is dynamically regulated by several environmental cues, including odors, tastes, temperature, and nutrient states (Avery and Horvitz 1990; Jones and Candido 1999; Li et al. 2012).
The ability to properly detect whole-body energy and nutrient states, i.e., metabolic sensing, is crucial for these first-order hypothalamic neurons to manage energy balance.
All these issues suggest that understanding the biology of yeast, considering the pressures that shaped its biology, require exploring the ways yeast cells respond to challenging conditions and the means by which they make transitions between different nutrient states.
Interestingly, these pathways also exist in the kidney [ 6– 9], and tissue concentrations of glucose, amino acid, AMP, and NAD+ are modified by particular nutrient states, such as diabetes, and diet therapies, such as protein or dietary restriction.
These results demonstrate that MED13 plays a central role in the regulation of cardiac metabolism by increasing utilization of fuel that is most readily available with alternating nutrient states (Fig 4J).
Similar(54)
Together, our results provide a foundation for studying gustatory processing and its modulation by the internal nutrient state.
In crystal growth theories,[2] for example, dissolved nutrient is postulated to pass through the "adsorbed nutrient" state before incorporation into the crystal structure.
Appropriate metabolic allocations require an assessment of the nutrient state of the animal, and nutrient sensing must be tied to appropriate signals in order to coordinate the repertoire of behaviors and physiologies accompanying a particular metabolic investment.
Circadian gene expression in peripheral tissues is intimately connected to feeding and the nutrient state [6], [7], [8], [48].
Even though the ribosomal transcription is high, it fluctuates with cellular state, being regulated by growth-factor signalling, nutrient state and stress [14] [17].
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