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We developed two versions of controller, both of which have glucose nutrient sensors but differ in their substrate-sensing modules.
We hypothesized that gestationally programmed nonalcoholic fatty liver disease in low-birthweight offspring is mediated through nutrient sensors nicotinamide adenine dinucleotide+ dependent histone deacetylase (SIRT1) and AMP-activated protein kinase (AMPK).
This regulatory network probably functions to provide cells with the flexibility necessary to respond to different inputs from two global nutrient sensors.
NR are ligand-activated transcription factors that act as nutrient sensors and, by responding to both incoming dietary signals and metabolites generated by the diet, play a key role in the metabolic adaptation of the organism [39].
Little is known about the mechanisms involved in the regulation of de novo lipogenesis in adipose tissue in response to diet but the hepatic transcription factors sterol regulatory element binding protein 1c (SREBP1c) and ChREBP have been proposed as nutrient sensors for de novo lipogenesis [43] [45].
Hence, they function as pure nutrient sensors.
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In cells, O-GlcNAcylation is often referred to as a nutrient sensor.
Phosphorylation of TSC2 by AKT thus provides a direct link between insulin signaling and the nutrient sensor mTOR signaling cascade (Astrinidis and Henske, 2005; Taguchi and White, 2008).
Glucose stimulates mTORC1, an important nutrient sensor involved in the regulation of cellular stress.
Data obtained from studies in both the mouse and the worm suggests that TMEM135 might function as a nutrient sensor and a metabolic regulator gene.
The mTOR pathway is the "nutrient sensor" of the cell and proximate targets of the pathway are responsible for both terminal oligopyrimidine (TOP) and cap-dependent translation of proteins (Figure 1) [17].
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