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Besides its direct effect on metabolism, nutrient deprivation causes endoplasmic reticulum (ER) stress in the microenvironment.
Nutrient deprivation during early development has been associated with the predisposition to metabolic disorders.
Thus, cells in the microenvironment are challenged by the cell-death-inducing effects of nutrient deprivation.
Sirtuins are activated in response to nutrient deprivation or energy deficit which triggers cellular adaptations to improve metabolic efficiency.
Hence, native soil bacteria constantly face nutrient deprivation.
Autophagy is typically activated by fasting and nutrient deprivation [22].
Maternal nutrient deprivation has been well characterised in this context.
The effect of maternal deprivation inevitably leads to nutrient deprivation.
During development, adverse environmental conditions like nutrient deprivation, hypoxia and increased protein secretion occur.
In contrast, there is no overlap between genes induced by nutrient deprivation and the DosR regulon.
Conversely during nutrient deprivation, stored triglycerides are hydrolyzed into fatty acids and converted back to energy.
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