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Acquired or de novo resistance to platinum-based chemotherapy is commonly observed in ovarian cancer, with numerous underlying mechanisms now proposed to explain this phenomenon, including drug inactivation, elevated resistance to apoptosis, decreased recognition of DNA damage, and increased DNA repair [ 8, 9, 53, 54].
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Potential underlying mechanisms are numerous.
Although the anti-tumor activities of adiponectin have been suggested by numerous clinical and experimental evidences, the underlying mechanisms remain to be established.
Since their discovery almost three decades ago, numerous alterations in miRNA expression with varying underlying mechanisms were associated with human malignancies [ 1].
The risk of dementia in older persons with DM is significantly higher than in those with NGT[2] and numerous investigations have been undertaken to determine the underlying mechanisms for such risk.
The underlying mechanisms involved are unclear, but numerous mediators/mechanisms have been proposed, including TGF-β (Lee et al., 2004), Fas activation (Maeyama et al., 2001), angiotensin II (ANGII) and reactive oxygen species (Waghray et al., 2005).
The search for the underlying mechanisms and the possibility of analyzing network dynamics in vitro has been subject of numerous studies.
The underlying mechanisms are unclear.
The underlying mechanisms remain unclear [63].
However, the underlying mechanisms remain elusive.
The underlying mechanisms are still unclear [8].
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