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In the literature, numerous trials using neuroimaging techniques have investigated brain function in patients with post-traumatic stress disorder (PTSD).
A considerable amount of dispute remains to ascertain the appropriate therapeutic regimen for treating postcraniotomy pain in spite of numerous trials using different drugs and their combinations.
In attempts to improve the efficacy of the treatment, numerous trials using modified approaches of chemoradiotherapy have been conducted (Chakravarthy and Abrams, 1997; Okada, 1999).
Furthermore, numerous trials using similar gene vectors to transfer genes into mature T cells have not been complicated by clonal outgrowth.
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numerous clinical trials using cytotoxic chemotherapy or targeted agents have failed, except sorafenib [ 21].
Numerous phase II trials using neoadjuvant chemoradiation showed marked downstaging and suggested survival benefits.
Numerous large clinical trials using anticoagulant agents, such as recombinant human activated protein C (rhAPC) [ 4], tissue factor pathway inhibitor [ 5], and antithrombin (AT) [ 6], have been conducted over the past 10 years to evaluate mortality benefit for patients with severe sepsis.
Since 2010, the above list has grown to include several immunotherapies and numerous pathogen-specific vaccines and cancer trials for recruiting children to clinical trials using the same reductionist and chaotic approaches for young patients (Khatami, manuscript in preparation).
Daphnia delivery was conducted in a standard manner in all trials, using Pasteur pipettes pre-filled with a suspension of numerous live Daphnia.
Trials using sticky chemicals have proved futile.
Trials using ipilimumab combined with various cytotoxic chemotherapies, such as temozolomide plus doxycycline (NCT01590082) or fotemustine (NCT01654692) are underway in patients with metastatic melanoma, as are numerous trials of PD-1 pathway inhibitors plus chemotherapy or targeted agents [ 16].
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