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Many of these transcripts represented portions of the genome that were not previously recognized as being, or predicted to be, transcribed, and included numerous transcripts in antisense orientations.
Consequently, these data are a strong indication that interindividual variation in methylation at repetitive elements is the default condition, rather than a rare occurrence, and that shifts in methylation profiles could affect numerous transcripts in the genome.
Spinal muscular atrophy and some forms of retinitis pigmentosa display tissue-specific phenotypes due to mutations affecting both spliceosomes and the processing of numerous transcripts in all cell types (Boulisfane et al, 2011; Linder et al, 2011).
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This is in line with the observed down-regulation of numerous transcripts involved in cell cycle regulation in general (S3).
Hence, while a loss of Esrp expression is likely to play a major role in splicing of numerous transcripts, alterations in expression of some of these other candidate regulators may also contribute to splicing shifts in some targets.
BLAST searches using these criteria uncovered the presence of numerous transcripts conserved in Bacillales or more frequently in Firmicutes (Table S1).
There were also marked changes in the expression of numerous transcripts involved in antioxidative defence, most of which were downregulated.
Later in life different immune transcripts were highly up-regulated in C. calcarata mothers, as well as numerous transcripts involved in neuronal differentiation.
Furthermore, the transcript abundance of numerous transcripts involved in starch metabolism changed during berry development.
Numerous transcripts exhibit differences in relative expression levels (either over or under expression) in each of the three individual pair wise comparisons (GvC: 2929 differentially expressed transcripts, DvC: 4019 and GvD: 5193).
We identified numerous transcripts putatively involved in the circadian rhythm oscillatory system.
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