Sentence examples for numerous target proteins from inspiring English sources

This linker helix has been hypothesized to act as a flexible tether and is crucial for the binding and activation of numerous target proteins.

Target arginines have been identified in numerous target proteins.

Cyclin A regulates cell cycle progression in association with cyclin-dependent kinases by binding and phosphorylation of numerous target proteins.

The 14-3-3 14-3-3 14-3-3is found in all eukaryotes and functions by interacting directly with numerous target proteins, thereby alteringeneeis activity.

Cyclin A is a key regulator of cell cycle progression and functions in association with cyclin-dependent kinases by phosphorylation of numerous target proteins.

Ubiquitination involves the covalent attachment of ubiquitin, a 76 amino acid protein, to numerous target proteins in a specific fashion to regulate their half-life, localization, activity and conformation [ 1, 2].

ROCK controls actin-cytoskeleton assembly and cell contractibility by phosphorylating numerous downstream target proteins [3], such as the regulatory myosin light chain (MLC) and the actin-binding LIM kinases.

GSK-3 is a pluripotent serine threonine kinase with a numerous intracellular target proteins (Jope and Johnson, 2004).

Expression of high-risk E6 and E7 proteins can immortalise primary human epithelial cells in vitro (Hawley-Nelson et al, 1989) and both proteins bind to numerous cellular target proteins (Kuhne and Banks, 1999; Zwerschke and Jansen-Durr, 2000), several of which are also targets of adenovirus and SV40 early proteins.

The Rho-associated coiled-coil containing protein kinase (ROCK) serine/threonine kinase is a major downstream effector of Rho GTPases that controls actin cytoskeleton assembly and actomyosin contractility via the phosphorylation of numerous downstream target proteins, including the myosin light chain (MLC) and actin-binding Lin11, Isl-1, and Mec-3 domain (LIM) kinases.

Using IPP and mass spectrometry, the authors identified these proteins as small ubiquitin-like modifier activating enzyme 1 and 2 (SAE) that are involved in the post-translational modification of numerous targets, including protein kinases and transcription factors [ 49].