Sentence examples for numerous target genes from inspiring English sources
The constitutive androstane receptor (CAR, NR1I3) plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes.
Arm and dTcf regulate the transcriptional activation of numerous target genes [3], [8], [9].
Each miRNA can regulate numerous target genes and therefore has the potential to modulate multiple pathways.
When heterodimerized with Max, Myc regulates the expression of numerous target genes involved in aspects of tumorigenesis including cell cycle regulation, cell growth, cell adhesion, immortalization and genomic stability (reviewed in [41]).
However, other SRTFs, including NF-AT, AP-1, and STAT-1, have also been implicated [26], [27], [28] by activating numerous target genes that encode mediators of inflammation and apoptosis, which underlie destruction of islets and other target tissues.
Our work suggests, in accordance with previous analyses [25] that the Qrr1 trans-band is not caused by just one master regulator, but is due to several polymorphic genes that either independently or in a concerted way affect the expression of numerous target genes.
Heterodimers of ARNTL/CLOCK gene products activate transcription of numerous target genes that in turn show circadian patterns of expession either directly via E-box regulatory element in their promoter regions, or indirectly by other transcription factors whose expression is under clock control [63], [64].
HNF6 contains a bipartite onecut-homeodomain sequence and binds to specific DNA sequences of numerous target gene promoters [ 5].
PH has numerous potential target genes, as yet largely uncharacterized functionally.
The analysis of modulated genes revealed that numerous Nrf2 target genes, including HO1, TXNR, NQO1 and γ GCS-L were up-regulated in fibroblasts while only NQO1 was slightly (but significantly) induced in keratinocytes.
There are numerous putative target genes for a given microRNA.
