There are numerous target substances and it is impossible to develop the necessary knowledge and methodologies solely at the national scale.
The positioning of the numerous target discs has to be done with accuracy better than ±200 μm and with a minimum of material around the targets.
The constitutive androstane receptor (CAR, NR1I3) plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through modulating the transcription of its numerous target genes.
Arm and dTcf regulate the transcriptional activation of numerous target genes [3], [8], [9].
Each miRNA can regulate numerous target genes and therefore has the potential to modulate multiple pathways.
Numerous target molecules have been implicated in organ-specific tumor metastasis but its detailed mechanism remains obscure.
Thus, there are numerous target sites that upon Etoposide treatment are bound by p53 that is phosphorylated at S46 to a higher extent than upon Actinomycin D treatment.
When heterodimerized with Max, Myc regulates the expression of numerous target genes involved in aspects of tumorigenesis including cell cycle regulation, cell growth, cell adhesion, immortalization and genomic stability (reviewed in [41]).
However, other SRTFs, including NF-AT, AP-1, and STAT-1, have also been implicated [26], [27], [28] by activating numerous target genes that encode mediators of inflammation and apoptosis, which underlie destruction of islets and other target tissues.
Our work suggests, in accordance with previous analyses [25] that the Qrr1 trans-band is not caused by just one master regulator, but is due to several polymorphic genes that either independently or in a concerted way affect the expression of numerous target genes.
Heterodimers of ARNTL/CLOCK gene products activate transcription of numerous target genes that in turn show circadian patterns of expession either directly via E-box regulatory element in their promoter regions, or indirectly by other transcription factors whose expression is under clock control [63], [64].
