Sentence examples for numerous substrates including from inspiring English sources

Cdk5 has specifically been implicated in exocytosis and endocytosis via phosphorylation of numerous substrates including synapsin, amphiphysin I, dynamin, and others [44] [47].

This differed from other work showing that RPMI 8866 cell adhesion to various substrates is inhibited by anti-ITGA4 antibodies; anti-ITGB7 antibodies have similar significant inhibitory effects whereas anti-ITGB1 antibodies do not affect RPMI 8866 cell adhesion to numerous substrates, including ADAMs [35], [36], [39].

One view is that VEGFR2 is a more potent tyrosine kinase which targets numerous substrates including membrane proteins, cytoplasmic enzymes and regulators [ 2, 62].

SULT1A1 plays a major role in biotransformation of numerous substrates including several carcinogens, neurotransmitters, steroid hormones and drugs (Raftogianis et al, 1999; Hildebrandt et al, 2007).

Phosphorylated zeta serves as a binding site for ZAP-70 (Chan et al., 1992), which then phosphorylates numerous substrates including linker of activated T cells.

Many of the diverse functions of CDK5 activity occur via phosphorylation of numerous substrates, including cytoskeletal proteins (e.g., nestin, doublecortin (DCX)), synaptic proteins (e.g., synapsin I, PSD95), and transcription factors (e.g., MEF2).

Each of the vertebrate MMPs has distinct but overlapping functions and substrate specificities, and together they can cleave numerous extracellular substrates, including virtually all extracellular matrix proteins [3].

Calpains have numerous protein substrates including G-proteins and cytoskeletal proteins such as spectrin, integrin and MAP-2.

Those are considered to be the key effect of proteases on apoptosis through the degradation of numerous cellular substrates including the cleavage of PARP.

Human UGT proteins glucuronidate numerous endogenous substrates including steroids and bile acids, as well as diverse xenobiotic chemicals such as environmental carcinogens and therapeutic drugs [ 20].

Activated Akt then phosphorylates numerous downstream substrates, including glycogen synthase kinase-3 (GSK3 α/ β), tuberous sclerosis complex-2 (TSC2), Foxo-family transcription factors, Bad, Par-4, PRAS40 and TBC1D4 (Manning and Cantley, 2007).