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However, while numerous substrates for the mammalian cell death-associated caspases have now been described, few caspase substrates have been identified in other organisms.
While numerous substrates for human and mouse caspases have now been identified [9], [10], it is not clear whether the same subset of proteins is targeted for proteolysis by caspases in other organisms.
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Unlike the numerous substrates of SIRT1, SIRT3 just has few specific substrates.
This review summarizes the role and numerous substrates of Hsp104-mediated protein disaggregation.
The great number of dehydrogenases available makes the concept applicable for numerous substrates to analyse.
As shown for numerous substrates, these CTFs or NTFs may then be subject to further proteolytic processing (RIPping) by intramembrane-cleaving proteases (I-CLiPs) [ 78].
SAM biosynthesis is regulated by one-carbon metabolism, a biochemical pathway for the methylation of numerous substrates that is dependent on folate for the recruitment of methyl groups from serine (Chiang et al. 1996).
Many transporters have multi-specificity towards numerous substrates thus the clinical outcomes for transporters like aforementioned ABCG2 may reflect only a portion of their physiological function (Table 1).
These results demonstrate that BACE1 is responsible for shedding numerous substrates, but that not all type I membrane proteins, even if shed by other secretases, can undergo β-secretase processing.
GSTK1 belongs to the glutathione S-transferase (GST) gene family that are critical for detoxification via conjugation of reduced glutathione (GSH) with numerous substrates such as pharmaceuticals and environmental pollutants [ 35].
Phosphorylated zeta serves as a binding site for ZAP-70 (Chan et al., 1992), which then phosphorylates numerous substrates including linker of activated T cells.
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Justyna Jupowicz-Kozak
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