Sentence examples for numerous subgroup analyses from inspiring English sources

Numerous subgroup analyses of different endpoints, dose groups, and subgroup populations may lead to the multiplicity issue.

Although numerous subgroup analyses by setting, drug class, disease, age, country, and publication year were undertaken, similar results were observed and these factors only partially explained some of the variation between studies (Table  1; Figures  2 and 3).

Numerous subgroup analyses have been conducted in an effort to identify those patients deriving the most substantial benefit from bevacizumab (O'Shaughnessy et al, 2009, 2010a, 2010b; Miles et al, 2010b).

22 Although all analyses conducted were based on an a priori specified analysis plan, the numerous subgroup analyses in this study might lead to a risk of finding isolated significant associations because of chance alone.

We also attempted a network meta-analysis for the dyspnoea outcome, yet the results were unreliable so are not presented here, despite numerous subgroup and sensitivity analyses.

We conducted numerous sensitivity and subgroup analyses to investigate clinical and methodological heterogeneity and to investigate risk of bias within and across studies.

Lastly, studies that failed to demonstrate a statistically-significant difference for the main outcome measure often performed numerous post hoc subgroup analyses, a practice that negates the rigor of statistical hypothesis testing.

Despite only 2 RCTs, there were numerous secondary publications [ 17- 30] involving subgroup analyses based on the PROWESS [ 13] trial.

Confounding by diagnostic intensity, particularly PSA testing, is a major concern in studies that compare Vietnam veterans with the general population, as well as in the subgroup analyses of the Air Force Health Study, where chance (given probable testing of numerous subgroups) is another important potential explanation for the reported associations.

No subgroup analyses based on insulin type used were possible, as changes were frequent, occurred multiple times in numerous patients and may have been dependent on the availability of particular insulin preparations.

In evaluating trials of new drugs and procedures, the Food and Drug Administration does not accept such subgroup analyses, requiring a second trial for the subgroup that may benefit.