Enriched pathways among overexpressed genes consisted of numerous stress responses such as DNA repair/SOS response, heat shock, phage shock, and envelope stress.
Genes down-regulated with TCE exposure appear to be those associated with cellular housekeeping, cell adhesion, and developmental processes, whereas TCE exposure up-regulated expression of numerous stress-response and homeostatic genes.
Chronic N stress induces a range of plant stress responses which include the transcriptional regulation of numerous stress responsive genes.
And ABA, a key plant stress-signalling hormone, is synthesised in response to various abiotic stresses and regulates the expression of numerous stress-responsive genes in plants [ 37].
Numerous stress-responsive candidate genes were obtained.
Gene expression microarray analysis revealed that numerous oxidative stress response genes were upregulated upon rapamycin treatment, including superoxide dismutase 1, glutathione reductase, and delta-aminolevulinate dehydratase.
The diversity of stress stimuli capable of triggering JNK1-mediated autophagy is consistent with the hypothesis that autophagy regulation is intricately intertwined with numerous other cellular stress response programs mediated by JNK1 signaling.
Based on the findings detailed above, we hypothesized that the decreased lifespan is likely due to cumulative effects of altered expression of genes involved in numerous developmental and stress response pathways, possibly including the de novo synthesis of the antioxidant glutathione.
By contrast, Deinococcus seems to have acquired numerous genes related to stress response systems from various bacteria.
Although they lack an adaptive immune system, they have evolved numerous other mechanisms of stress response and defence.
