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CD44, a transmembrane glycoprotein and major ligand for hyaluronan, has numerous splice variants which may impact hyaluronan binding.
Bioinformatic investigations have identified numerous splice variants, but whether these transcripts are translated to functional proteins and the physiological significance of these alternative proteins are largely unknown.
More commonly, they and other SINEs are incorporated into mRNA UTRs and coding regions as cassette exons [5], [8], [9], [52], facilitated by the presence of numerous splice donor and acceptor sites in the sense and antisense orientations [10].
Numerous splice variants of ERβ have also been described.
Of the numerous splice variants transcribed from the BDNF gene, the transcript containing BDNF exon VI, was most aberrant in post-PNS animals.
6 12 VEGF-A is a critical pro-angiogenic factor secreted as numerous splice isoforms that together regulate the phenotype and efficacy of growing vascular networks.
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The existence of numerous splicing variants underpins the complexity of the morphinergic system [57], [60], [61].
Second, the protein families represented in today's sequence databases are often more complex, with multidomain architectures, large unstructured (natively disordered) regions, numerous splicing variants, etc. Third, the new sequences are mostly predicted by automatic methods and thus, contain a significant number of sequence errors [33], [34].
We also looked at splice-site SNVs and detected numerous splice-site SNVs that could cause improper splicing.
Numerous splicing variants of the NOS1 gene have been described (Forstermann et al, 1998).
This is consistent with previous reports showing a coordinated regulation of RNA splicing by numerous splicing factors [ 38].
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