Sentence examples for numerous somatic mutations from inspiring English sources

Cancer is a genetic disease, with numerous somatic mutations in proto-oncogenes and tumor suppressor genes contributing to the malignant phenotype [1].

All of these light chains contain numerous somatic mutations.

Previous work highlighted numerous somatic mutations [ 12] and DNA copy number alterations (CNAs) [ 13] that are linked to specific intrinsic subtypes, suggesting that these genetic events may be causative of these subtypes.

Further evidence for an early involvement of p300/CBP in nonviral cancers can be observed in the increased predisposition to childhood malignancies in Rubinstein–Taybi syndrome, which is characterised by germline mutation of CBP as well as numerous somatic mutations in colorectal, breast and gastric carcinomas (Iyer et al, 2004).

Numerous somatic mutations in both the coding and control regions of mtDNA have been extensively examined in a broad range of primary human cancers, underscoring the fact that accumulation of mtDNA mutations may be a critical factor in eliciting persistent mitochondrial defects and consequently contributing to cancer initiation and progression [ 55].

Because cancer cells are genetically unstable and accumulate numerous somatic frameshift mutations in genes with an expected role in cell transformation, the NMD system has been proposed to play a role in tumor development [12].

Recent studies involving deeply sequencing the tumor genomes from acute myeloid leukemia patients (Ley et al., 2008; Mardis et al., 2009) and a lobular breast cancer patient (Shah et al., 2009b) have revealed numerous novel somatic mutations in genes that had not been previously reported to harbor abnormalities.

For full variants in ovarian cancer samples, see Supplementary Table 2 AllVariants Numerous studies report somatic mutations in mtDNAs from colorectal cancer patients (Alonso et al. 1997; Polyak et al. 1998; Lièvre et al. 2005; He et al. 2010; Wang et al. 2011) but the correct pattern of COAD-associated mutations has not been yet reconstructed (Skonieczna et al. 2012).

In recent years, numerous studies have investigated somatic mutations in mitochondrial DNA in various tumours.

In our comprehensive genomic analysis of IMPCs of the breast, we identified numerous genomic alterations and somatic mutations, but no recurrent fusion gene.

To address this important question, we took advantage of the data in COSMIC, which is the most comprehensive, annotation-based database for the somatic mutations from numerous patients with cancer type information.