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This avenue of research is markedly enhanced by the existence of numerous small molecule antagonists that are available to selectively target these receptors.
Phospholipids (PL) are among the numerous small molecule signals that are accountable for the precision and effectiveness of cellular life and death decisions.
Numerous small molecule therapeutics against the filoviruses have been described, some with demonstrated efficacy in nonhuman primates.
The identification of protein kinases as instrumental regulators in the tumorigenesis of many forms of neoplasia has led to the development of numerous small molecule kinase inhibitors for the treatment of cancer.
For example pyruvate kinase and phosphofructokinase have numerous small molecule effectors and post-translational modifications that affect their activities (Mor et al., 2011; Chaneton and Gottlieb, 2012; Keller et al., 2012; Yi, et al., 2012).
Numerous small molecule inhibitors that target specific tyrosine kinases, tyrosine kinase inhibitors (TKIs), have successfully been used for the treatment of human and canine cancers with mutations in KIT [ 45, 46].
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Overall, numerous small molecules have been developed that induce a key step of salamander limb regeneration, cellularization, in mammalian muscle tissue.
The functionalization layers on surface of nanoparticles are commonly composed of numerous small molecules that interact with a specific target protein.
In order to uncover the richness of biological activities within existing chemical libraries, we performed a broad, phenotype-based screen on zebrafish embryos and identified numerous small molecules that perturbed a wide variety of different processes during development.
Numerous small molecules are measured that can be both endogenous and exogenous.
The numerous small molecules that are used for so-called "mitochondrial pharmacology" modulate various mitochondria-confined processes.
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