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Quantitative trait locus (QTL) models can provide useful insights into trait genetic architecture because of their straightforward interpretability but are less useful for genetic prediction because of the difficulty in including the effects of numerous small effect loci without overfitting.
This is especially important if the missing heritability of tocochromanol traits in the association panel is predominantly explained by numerous small effect QTL (Buckler et al. 2009; Yang et al. 2010).
In crosses between cultivated and wild sunflower, branching has been found to be a genetically complex trait influenced by numerous small effect loci distributed throughout the genome [ 19, 20].
The reported results showed that the marker density provided by the consensus map was sufficient to identify chromosome regions harboring numerous small effect QTLs for heading date, at a resolution level not possible with traditional bi-parental mapping studies.
Therefore, to prevent biological fluctuation due to a single polymorphism mutation, a network with multiple cross-talking actors as a product of evolution without human selection could be postulated in the case of seed PAs, as suggested by the identification of numerous small effect QTLs and the involvement of epistasis.
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[c] Complex PGx traits resemble most multifactorial quantitative traits –– influenced by numerous small-effect variants, together with epigenetic effects and environmental factors.
The US-NAM analysis of maize flowering-time traits argued for numerous small-effect QTLs with additive effects [ 9].
Validation of the entire network of interactions, however, is likely to remain a monumental task due to the numerous small-effect QTL involved and their environmental unpredictability.
Previously, numerous small-effect QTLs were identified for flowering time in US-NAM, phenotyped for flowering time in six different US environments [ 9].
Therefore, CN-NAM results supported the earlier US-NAM finding that flowering-time traits of NAM populations were controlled by numerous small-effect QTLs with additive effects.
First, do genes of large effect give rise to the observed changes, or are they governed by numerous small-effect loci that are additive in nature (as predicted by Fisher).
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