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While studying large changes (eg, big deletions, inversions, and translocations at the chromosomal level) in tumor cells is informative, knowledge of the more numerous small alterations that occur at the nucleotide sequence level are equally or more critical to our understanding of the detailed process of carcinogenesis, particularly at its earliest stages.
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Analysis of SNpC cytology identified an obvious alteration in the cytoplasmic morphology of TH-positive neurons in Id2−/− mice, characterized by numerous small, dark-staining cell bodies (Fig. 3A, arrows).
Small alterations can have big effects.
All appear to produce numerous small eggs.
Numerous small stakeholders make for unwieldy organisation.
A fixed set undergoes small alterations for scene shifts; sly little jokes on perspective are played.
In addition, we observed small alterations in some of the biophysical properties of the channel.
On one wall, there are numerous small still-life paintings.
There are also the State Gallery of Modern Art and numerous small art galleries.
Surrounded by hills, Seoul has numerous small and large parks.
For additional comfort, there are numerous small, strange velvet pillows.
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