Numerous signaling pathways converge to affect the levels and posttranslational modifications of Bcl-2 family proteins.
Endogenous uterine agonists can activate numerous signaling pathways to effect increased force.
Interaction of numerous signaling pathways in endothelial and mesangial cells results in exquisite control of the process of physiological angiogenesis, with a central role played by vascular endothelial growth factor receptor 2 (VEGFR-2) and its cognate ligands.
However, this relationship remains mostly undefined in the context of breast cancer, as protein degradation is mediated by numerous signaling pathways as well as certain molecule modulators (activators/inhibitors).
The ER is also in constant motion, and numerous signaling pathways as well as interactions among cytoskeletal elements, the plasma membrane, and organelles cooperate to position and shape the ER dynamically.
Numerous signaling pathways, additional metabolic and mitochondrial dysfunctional pathways are also manifest, suggesting that a wide range of canonical pathways may be involved in the response to infection.
Although disruption of MAPK signaling alters numerous signaling pathways and transcription, the activating danger signal(s) that induce pyroptosis are unknown.
Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, regulates numerous signaling pathways involved in cell cycle control, proliferation, differentiation and apoptosis [25], [26].
Central nervous system (CNS) development is orchestrated by numerous signaling pathways, including the Shh signaling pathway, which in mammals is mediated by the transcription factors Gli 1, 2, and 3 (reviewed in [1] [3]).
Williams et al. [31] suggested that while induction of HSP70 may help keep hyperthermic cells alive, it may also overstimulate or inhibit numerous signaling pathways involved in cell proliferation, maturation and death, resulting in developmental failure [58].
The enzyme which comprises two isoforms, GSK-3α and GSK-3β, has since been implicated in many different biological processes including developmental patterning and cell survival as a regulatory switch that integrates numerous signaling pathways [5].
