Sentence examples for numerous sequence variants from inspiring English sources

The downside of these technologies is that they will yield numerous sequence variants of unknown significance.

Clemmer and co-workers applied conventional ion mobility to the analysis of large peptide libraries containing numerous sequence variants.

Furthermore, PKD1 is a highly polymorphic gene with numerous sequence variants [ 10, 11] (Human Gene Mutation Database [HGMD]; http://www.hgmd.cf.ac.uk/ac/index.php[ 12]).

Genomic DNA sequencing of the SAMHD1 gene in all study subjects revealed numerous sequence variants in all three groups (see Supplemental Table e-1 available online at http://dx.doi.org/10.1155/2015/739586).org/10.1155/2015/739586

Numerous sequence variants were found with an average frequency of 1 in 244 base pairs (bp), and 40% of these were low-frequency variants (i.e., minor allele frequency [MAF] <5%).

Highly expressed Anopheles miRNAs (e.g. bantam or miR-263a) are represented by numerous mature sequence variants that vary in their abundance across all analyzed libraries.

Although modern sequencing technologies permit the ready detection of numerous DNA sequence variants in any organisms, converting such information to PCR-based genetic markers is hampered by a lack of simple, scalable tools.

Interpretation of variants present in complete genomes or exomes reveals numerous sequence changes, only a fraction of which are likely to be pathogenic.

Numerous computational approaches have been developed and applied in the search for sequence variants that play a role in phenotypes of interest.

Apoptosis-associated sequence variants, when considered individually, may minimally influence the risk of developing numerous cancers, such as multiple myeloma, squamous cell carcinoma, chronic lymphocytic leukemia, non-Hodgkin lymphoma, colorectal, ovarian, breast, pancreatic, and non-small cell lung [ 20- 37].

This requires the development of powerful bioinformatic approaches that allow prediction of haplotypes from numerous variants, and the classification of haplotypes into functionally related categories, in order to identify those specific sequence variants, or combinations of variants, associated with the disease phenotype.