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FOXM1 is a highly conserved forkhead transcription factor that regulates the expression of numerous regulators of cell cycle progression, particularly in the G2 phase [ 49].
Numerous regulators of presynaptic terminals at neuromuscular junctions (NMJs) have been identified.
Altogether, such data strongly indicate that plant total and polysomal transcript profiling will help to identify numerous regulators of the DNA damage response.
Their target genes include numerous regulators of biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, development, and immunity [ 7, 8].
This may reflect the fact that Toca-1 is capable of scaffolding and activating numerous regulators of actin assembly at cell protrusions that facilitate motility and invasion.
Although Drosophila cell RNAi screens identified numerous regulators of cellular morphology and the actin cytoskeleton [ 28 30], in vivo roles for many regulators have not been investigated.
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During neuronal morphogenesis, the formation and outgrowth of functionally and structurally distinct axons and dendrites require a coordinated and dynamic reorganization of the microtubule cytoskeleton involving numerous regulators.
There are numerous positive regulators of cell growth, including growth factors, metabolic resources, oncogenes, and the telomere repair system.
There are numerous key regulators of mitochondrial biogenesis, including peroxisome proliferator-activated receptor gamma (PPARγ) co-activator 1 alpha (PGC1α), AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), nuclear respiratory factor 2 (NRF2) and mitofusin 2 (MFN2).
The advantage of having the fully sequenced C. elegans genome has permitted the identification of numerous genes encoding regulators of fat storage and transport as well as neuroendocrine regulators of fat and food-related behaviors, many of which have mammalian homologs (Mullaney and Ashrafi 2009).
MicroRNAs are small ∼22 nucleotide regulators of numerous biological processes and bind target gene messenger RNAs to control gene expression.
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