Although Drosophila cell RNAi screens identified numerous regulators of cellular morphology and the actin cytoskeleton [ 28 30], in vivo roles for many regulators have not been investigated.
This may reflect the fact that Toca-1 is capable of scaffolding and activating numerous regulators of actin assembly at cell protrusions that facilitate motility and invasion.
The positive regulation of KRP6 and CYCB1 1 accompanied the arrest together with numerous regulators such as the novel Arabidopsis genes hCHFR-like and ScDDI-like (Fig. 8).
Centralspindlin organizes the spindle midzone and directly recruits numerous regulators of cytokinesis, including ECT-2, to this location (Burkard et al., 2009; Wolfe et al., 2009).
FOXM1 is a highly conserved forkhead transcription factor that regulates the expression of numerous regulators of cell cycle progression, particularly in the G2 phase [ 49].
During neuronal morphogenesis, the formation and outgrowth of functionally and structurally distinct axons and dendrites require a coordinated and dynamic reorganization of the microtubule cytoskeleton involving numerous regulators.
Altogether, such data strongly indicate that plant total and polysomal transcript profiling will help to identify numerous regulators of the DNA damage response.
Once infected, cells become tightly controlled by HCMV, expressing numerous regulators of the cell cycle, apoptosis, cell signaling pathways, antigen presentation, and so forth (see Table 1).
Their target genes include numerous regulators of biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, development, and immunity [ 7, 8].
However, numerous regulators of Noxa expression have been described, among them p53, c-myc, and E2F-1 [revinwed in [ 33]], and further experiments are needed to investigate whether these, or additional factors, are involved in Noxa induction on Notch inhibition.
