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Functional performance of a cortical area depends on a well-tuned and area-specific balance between numerous receptor types (Barnes and Sharp 1999; Goldman-Rakic et al. 2000; Gibbs and Summers 2002; Bergson et al. 2003; Bredt and Nicoll 2003; Friedman et al. 2004).
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It should be noted that opioid peptides interact with numerous opioid receptor types [23], [24], and that BE itself acts with the similar affinity at mu, delta and epsilon receptors.
Scientists have identified, isolated, or synthesized several different cannabinoids that bind to two main receptor types in the human brain.
This signaling pathway comprises numerous extracellular ligands (such as activin A, myostatin, nodal), transmembrane receptors [such as activin receptor type IIB (ActRIIB), TGFβ receptor type II] and intracellular signal transducers (SMAD proteins) (Schmierer and Hill, 2007).
γ-secretase substrates include numerous proteins known to regulate innate immune responses including notch, low-density lipoprotein receptor-related protein 1 (LRP1), interleukin-1 (IL-1) receptor type 1, IL-1 R2, CX3CL1, CXCL16, and the MHC class I protein, HLA –A2 [47], [48], [49], [50], [51], [51].
activin receptor type IIB.
ADCYAP receptor type I gene.
TGF-β receptor type III.
soluble interleukin-1 receptor antagonist receptor type II.
Scavenger receptor type 1. Tumor-associated macrophages.
Vasoactive intestinal peptide (VIP) receptor type 1. Vasoactive intestinal peptide (VIP) receptor type 2.
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