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Impulsivity is a key feature of numerous psychiatric disorders.
The aberrant regulation of glutamate has been implicated in numerous psychiatric disorders including drug addiction and attention-deficit/hyperactivity disorder.
5-HT is involved in the dysfunction of numerous psychiatric disorders and behavioral traits, such as MDD, suicide, or depression.
The role of Catechol-O-Methyltransferase (COMT) in dopamine metabolism has led to investigation of its variants in the etiology of numerous psychiatric disorders including psychotic, affective and anxiety disorders.
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They also play a significant role in cognition and its disruption has been demonstrated in numerous psychiatric and neurological disorders that present cognitive alterations, including schizophrenia [ 13], attention deficit hyperactivity disorder [ 14] or Alzheimer's disease [ 15].
Perturbations in synapse and circuit balance are associated with numerous neurological and psychiatric disorders, including epilepsy and autism spectrum disorder.
Alcohol use disorder remains a leading cause of morbidity and mortality in the U.S. and is a major comorbid factor in numerous medical and psychiatric disorders, including HIV infection.
Numerous neurological and psychiatric disorders have been related to genomic alterations [12].
This polymorphism was associated with numerous neurological- and psychiatric disorders, including ADHD [7], cocaine-induced paranoia [12], tobacco smoking [13], and alcohol dependence [14], however, the findings have not been consistently replicated and most of the studies reported no effect of this polymorphism on neurophysiologic and psychiatric measures.
Numerous neurological and psychiatric disorders show sex differences in incidence, age of onset, symptomatology or outcome.
Studies with mGlu7 knockout (KO) animals have predicted therapeutic potential for mGlu7 manipulation in numerous neurological and psychiatric disorders including schizophrenia, depression, anxiety, and epilepsy.
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