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The ability of EWS to interact with numerous proteins implicated in transcriptional regulation and RNA processing [24], [25], [26], [27], [28], [29] may supply an alternative explanation.
Numerous proteins implicated in the control of the cell cycle progression have been found to be mutated or misregulated in human tumors [ 7- 9].
Specific interactors also included numerous proteins implicated in membrane trafficking, primarily along the endocytic pathway and vesicular transport steps between endosomes and the Golgi complex (Supplementary file 1A,B).
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The molecular mechanisms whereby HuR modulates translation are not fully clarified, although it is clear that HuR regulates numerous genes encoding proteins implicated in carcinogenesis [ 20].
Through this phosphoproteomics approach, we were able to confidently identify close to 700 phosphoproteins in the CLL samples, including numerous proteins previously implicated in CLL disease.
This multiplicity of actions is supported by its numerous interactors, which comprise proteins implicated in membrane traffic, signaling and actin regulation in a variety of cellular compartments (Pirruccello and De Camilli, 2012).
As shown here, proteins implicated in clathrin-mediated endocytosis are prominently featured in the OCRL 'interactome', which also comprises numerous proteins that participate in the clathrin-dependent traffic between endosomes and the Golgi complex.
In addition to kinetochore proteins, numerous other proteins are integral to chromosome stability, including spindle checkpoint proteins, motor proteins, microtubule-associated proteins, regulatory proteins, and proteins implicated in CEN DNA chromatin dynamics, structure, and sister chromatid cohesion [1], [7], [14], [15].
A class of proteins implicated in processes such as ageing, apoptosis and inflammation.
Moreover, the effects of mTOR inhibition extend to other matrisome proteins implicated in the fibrotic response.
Numerous proteins have been implicated as having a crucial role in metastatic cancers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com