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Given the numerous processes involved, it would appear that much of the protein would show multi-state exchange profiles.
A single model component may represent a whole set of biological concepts (e.g. there are numerous processes involved in protein degradation, which is generally modelled as a single entity), while one biological process may require multiple model components (protein production involves transcription, translation and mRNA degradation components).
With the multitude of substrates targeted and the numerous processes involved, it is not surprising that aberrations in this pathway have been implicated in the pathogenesis of many diseases, such as cancer and, more specifically, breast cancer (Lipkowitz, 2002; Ohta and Fukuda, 2004; Mani and Gelman, 2005).
In order to perform high throughput screening of cell migration, we developed a wound healing assay in a 384 well plate format that does not require expensive reagents, provides consistently shaped wounds, can provide detailed information on numerous processes involved in cell migration, and provides a quantitative, information-rich readout.
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Numerous oceanographic processes involved in the transport and survival of larval stages of marine organisms, as well as, in nutrient and phytoplankton delivery, occur in nearshore waters.
From a thermodynamic viewpoint and among numerous cellular processes involved in cancers, two major phenomena play a key role, i.e., aerobic glycolysis or the Warburg effect and disruption of circadian rhythms (CRs).
Zinc signaling also modulates numerous cellular processes involved in cell differentiation, proliferation, and growth [ 54].
These observations provide a novel insight into the potential regulatory role of miRNAs in the numerous physiological processes involved in stress adaptation.
To illustrate how complex and self-operating free markets are, Kernen pays homage to Leonard Read's legendary 50-year-old essay elucidating the numerous efforts and processes involved in the manufacturing of the seemingly simple pencil.
Numerous physiological processes involving cellular invasion, blastocyst implantation, and placental development occur under reduced oxygen environments [71].
Consistent with this, aging in many organisms is modulated by conserved signaling pathways that affect numerous cellular processes, involving regulation of translation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com