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They have a highly complex tertiary architecture that enables them to catalyze numerous processes, including self-splicing and transposition reactions that have probably contributed to the evolution of eukaryotic genomes.
Prostaglandins are lipid molecules regulating numerous processes including modulation of immune function [1] [3].
CD44 isoform variations in cancer have been associated with the metastatic ability of tumor cells, being involved in numerous processes, including cell proliferation, adhesion and invasion [22].
Dopamine receptor mediated signaling is extensively regulated by numerous processes, including, endocytosis, whereby agonist activated receptors are rapidly silenced by removal from the cell surface to an endocytic compartment.
Macropinocytosis is involved in numerous processes including nutrient uptake and degradation [8], down-regulation of plasma membrane receptors following ligand binding [9], and antigen processing and maturation of dendritic cells [5], [10].
Amphibian metamorphosis is a late developmental event that has been used to examine numerous processes including; cell signaling, receptor function, gene regulation, morphogenesis, and effects of environmental toxins [1] [4].
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Proteolytic cleavage plays an essential role in the control of numerous biological processes, including protein localization, fate and activity as well as the processing of cellular information.
Pentameric ligand-gated ion channels (pLGICs) mediate numerous physiological processes, including fast neurotransmission in the brain.
RhoGTPases regulate numerous cellular processes including cytoskeleton organization, gene transcription, cell proliferation, migration, growth and cell survival.
Carbon monoxide (CO) is an endogenous signal transmitter involved in numerous physiological processes including the gastrointestinal (GI) homeostasis.
The effects of mutant IDH are pleiotropic and affect numerous cell processes including DNA methylation, histone methylation, HIF1a signaling, collagen synthesis, and metabolism (Cairns and Mak, 2013).
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