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In addition to the major findings of hypofrontality in patients obtained using brain imaging methods [1], numerous post mortem studies have shown alterations in the expression of genes and proteins involved in major energy metabolism pathways [2] [6], and studies of peripheral tissues have also detected metabolic alterations in first onset and drug naïve patients [7], [8].
Numerous post hoc studies have revealed some predictors of better responses, but the data are inconclusive (57– 60).
Numerous post hoc analyses have been unable to prove or disprove causes; in fact, the design of the study renders such "proof" elusive.
In these analyses from ACCORD, we found a remarkable similarity of effect on mortality of intensive compared with standard glycemia arm assignment across numerous post hoc baseline subgroups.
Lastly, studies that failed to demonstrate a statistically-significant difference for the main outcome measure often performed numerous post hoc subgroup analyses, a practice that negates the rigor of statistical hypothesis testing.
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