Sentence examples for numerous point mutations from inspiring English sources

Nonetheless, several fascinating papers that analyzed the genomic and transcriptomic landscape of primary prostate cancer and mCRPC identified numerous point mutations, translocations, and amplifications [5 11].

Many biovars of Y. pestis exist, varying between one another by significant changes including plasmid acquisition, while even within biovars, strains differ due to numerous point mutations, often in non-coding sequences [4], [5].

Numerous point mutations responsible for the disease were identified in the AS gene.

This comparison revealed not only which genomic DNA copy was expressed but also that the non-expressed copies displayed evidence of pseudogenization by having acquired numerous point mutations, insertions, and deletions likely resulting in gene loss through sequence degeneration.

We assembled parts of the element from Illumina reads, and these partial sequences contain numerous point mutations when compared with the 26 almost identical H3L repeats (43 mutations in four partial copies in SD20-NP and DW7-ToxB vs. 18 total mutations in 26 complete copies in the reference genome; Figure S3; data not shown).

The active spread of EAV-HP in modern chickens is believed to involve a helper virus due to the numerous point mutations, deletions and insertions in EAV-HP sequences inactivating viral gene products [ 3], and that none of the proviruses found to date have been observed to produce infectious virions [ 2].

However, this gene synthesis strategy (known as "assembly PCR") requires large amounts of chemically synthesized oligonucleotides, multiple rounds of PCRs, and often results in numerous unwanted point mutations due to the large number of synthesized bases and multiple rounds of PCRs[10], [11].

The loss of wild-type p53 function or gain of new oncogenic properties may result, in part, from the numerous missense point mutations within the DBD of p53 clustered into discrete hot spots (R175, G245, R248, R249, R273 and R282) (Tu et al, 2008).

RIP is a genome-defense mechanism that subjects recently duplicated sequences to numerous G C to A T point mutations and is thought to have evolved to suppress the amplification of transposable elements.

Indeed, although the majority of TNDM cases have an abnormality in chromosome 6q24 and the other most frequent causes of NDM are missense mutations in the pancreatic β-cell KATP channel genes KCNJ11 and ABCC8, and in the preproinsulin gene, NDM has been linked to numerous other genetic causes including point mutations in GCK, GLIS3, EIF2AK3, PDX1, PTF1A, SLC2A2, HNF1B or FOXP3 [2], [3], [3].

Numerous recurrent gene fusions and point mutations have been identified over the past several decades.