Numerous physiologic scoring systems have been developed and used widely in the ICU.
The febrile response, defined by Plaisance and Mackowiak, is a "complex physiologic reaction to disease involving a cytokine mediated rise in core temperature, generation of acute-phase reactants, and activation of numerous physiologic endocrinologic and immunologic systems" [ 15].
Behaviors produced by healthy physiologic systems, however, rely upon nonlinear interactions among numerous feedback loops and regulatory processes that operate over multiple temporal and spatial scales [ 24, 36].
Through their influence on the patterns of expressed genes, microRNAs have been implicated in numerous physiologic processes, such as develop-ment of the muscular, immune, neuronal, epithelial and other systems, and in pathologies including neuro-degeneration and cancer [ 5- 8].
This means that chronic sleep deficiency has the potential to impact nearly all of our physiologic systems.
Numerous physiologic and imaging-based modalities exist for the evaluation of patients with clinical suspicion of RAS [1].
Specific proteolytic processing of inactive precursors is an exquisite cellular mechanism that triggers the activation of numerous physiologic peptides and proteins.
Moreover, IGF-I enhances cell survival in the face of numerous physiologic insults that include DNA damage [10], [11] and loss of cell adhesion [12] [14].
Indeed, CLU has been implicated in numerous physiologic and pathologic processes important for carcinogenesis and tumour growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling and immune system regulation [ 5, 6].
During pregnancy, there are numerous physiologic changes that may affect BPA distribution, metabolism, and/or clearance.
