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Selecting optimal models enables accurate evaluation of associations between marker loci and numerous phenotypes including gene expression.

Aeromonas hydrophila, P. aeruginosa, and so forth, have been shown to use AHL-based quorum sensing system to regulate numerous phenotypes including biofilm formation [ 22, 44].

However, multiple phenotypes are commonly measured, and recent technological advances have greatly simplified the automated acquisition of numerous phenotypes, including phenotypes measured over time.

However, multiple phenotypes are commonly measured, and recent technological advances have greatly simplified the automated acquisition of numerous phenotypes, including function-valued phenotypes, such as growth measured over time.

Compared to Drosophila, the mammalian PcG genes have acquired novel functions during evolution because PcG knockout mice exhibit numerous phenotypes including hematopoietic defects, neural crest defects, cardiac anomalies, and sex reversal [ 12, 13].

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Technology developments have enabled the automated acquisition of numerous phenotypes, included function-valued traits, such as phenotypes measured over time.

In the mouse, MAGP-1 deficiency had little effect on elastic fibers in blood vessels and lung but resulted in numerous unexpected phenotypes including bone abnormalities, hematopoietic changes, increased fat deposition, diabetes, impaired wound repair, and a bleeding diathesis.

These human proteins were expressed in Rat1a fibroblasts, because this cell background has been routinely used to evaluate numerous Myc phenotypes, including anchorage-independent transformation and in vivo tumorigenesis [14], [15], [30], [31].

Differential methylation has also been linked to numerous other phenotypes, including smoking [ 21- 24], age [ 25- 30], and gender [ 31- 33].

Mutations in POLG, which lead to aberrant functionality are responsible for numerous disease phenotypes including Alper's syndrome and Progressive external ophthalmoplegia (PEO) [135,136].

This aspect is particularly interesting because dysfunctions of GABAergic neurons and an excitation/inhibition (E/I) imbalance contribute to numerous neuropsychiatric phenotypes, including epilepsy, autism spectrum disorder (ASD) and Rett's syndrome (7– 11).

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